Individual
DC projects
Research project
Characterization of AID-dependent Mutations on MicroRNA Function
Rationale and Objectives
MicroRNAs (miRNAs) are critical regulators in lymphoma development, acting as both oncogenes and tumor suppressors. The hypothesis driving this project is that miRNAs play a pivotal role in post-transcriptional regulation in B-cell lymphoma.
To investigate this, the following objectives are proposed:
- Characterizing the impact of activation-induced cytidine deaminase (AID) on miRNA expression and their altered target specificities.
- Investigating the role of AID-induced mutations in the transformation of neoplastic B-cells.
- Functionally assessing the effects of AID mutagenic activity on miRNA abundance and repertoires, and their impact on gene expression and lymphoma growth.
Estimated gross salary
42,000€/year
This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.