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Research project

Enhancing CAR-NK Cell Therapies to Target Acute Myeloid Leukemia and Overcome Immune Resistance

Rationale and Objectives

This project aims to improve CAR-NK cell therapies for AML by exploring AML-NK cell interactions and identifying strategies to enhance therapeutic efficacy.

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The specific objectives are:

  1. Investigating the ability of CAR-NK cells to target AML leukemia stem cells (LSCs) and explore modulation of immunogenic molecules, such as PARP1 inhibition, to enhance targeting.
  2. Examining immune escape mechanisms in AML-NK cell interactions using 3D organoid and xenograft models.
  3. Employing advanced techniques like multiplexed microscopy, single-cell RNA sequencing, and metabolomics to identify strategies to overcome immune evasion and improve NK cell therapy outcomes.

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Estimated gross salary

40,000€/year

This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.