Individual
DC projects
Research project
Determining the Long-lasting Impact of T-cell Leukemia and Lymphoma on Hematopoietic niches
Rationale and Objectives
At the peak of the disease, T-ALL and T-cell lymphoblastic lymphoma (T-LL) cells infiltrate and expand in key organs, including the thymus and bone marrow (BM). However, it remains unclear whether these organs fully recover in patients who are cured.
The primary objective of this research program is to investigate the extent and nature of cellular microenvironmental alterations in leukemia/lymphoma survivors. Using mouse models that can be cured of leukemia/lymphoma, the program aims to:
- Conducting an in-depth characterization of the thymus and BM microenvironments during and after disease resolution.
- Identifying long-term cellular damage resulting from prior leukemic cell infiltration.
- Predicting potential hematopoietic and immunological dysfunctions in individuals who have survived the disease.
Estimated gross salary
32,200€/year
This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.