Individual
DC projects
Research project
Investigating Mechanisms of Brain Infiltration and Chemotherapy Resistance in T-cell Acute Lymphoblastic Leukemia
Rationale and Objectives
This project seeks to identify molecular drivers of therapy resistance in brain-resident T-cell Acute Lymphoblastic Leukemia (T-ALL) cells, assess treatment effects on the blood-brain barrier (BBB), and find new therapeutic targets to prevent brain infiltration with minimal toxicity.
The specific objectives of this project are:
- Identifying molecular mechanisms driving therapy resistance in brain-resident T-ALL cells.
- Evaluating the effects of combined anti-leukemic treatments on both leukemia cells and the human BBB using humanized models.
- Identifying novel therapeutic targets to treat and prevent T-ALL brain infiltration while minimizing treatment toxicity.
Estimated gross salary
46,600€/year
This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.