Individual
DC projects
Research project
Defining the Mechanistic Impact of PTPN11 Mutations on Leukemic Transformation and Disease Progression in Juvenile Myelomonocytic Leukemia
Rationale and Objectives
The primary objective of this project is to investigate the oncogenic mechanisms driven by PTPN11/SHP2 mutations in Juvenile Myelomonocytic Leukemia (JMML), a myeloproliferative neoplasm of early childhood. Our lab has developed transgenic and xenograft mouse models to explore JMML’s prenatal origins and identify novel therapeutic targets.
Focusing on the specific role of SHP2 variants in distinct cellular contexts, the specific aims of this research program are:
- Dissecting how PTPN11 mutational diversity impacts downstream signaling pathways and JMML disease progression.
- Understanding how different SHP2 mutations influence leukemic transformation and therapeutic resistance using single cell multi-omics, mass spectrometry and phospho-proteomics.
- Investigating the functional impact of SHP2 mutations in JMML by performing CRISPR and drug screening.
Estimated gross salary
37,200€/year
This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.