Individual
DC projects
Research project
Mathematical Modelling of the Immunotherapies in Hematologic Malignancies
Rationale and Objectives
This project aims to develop a mathematical framework to optimize immunotherapy strategies for hematological cancers.
The key objectives are:
- Developing a data-driven mathematical model using ordinary differential equations to represent immune response dynamics in hematological malignancies.
- Analyzing the properties of the model and incorporating immunotherapy as a control mechanism to impact leukemia/lymphoma progression and immune function.
- Formulating and solving the optimal control problem to enhance immunotherapy strategies and improve outcomes.
Estimated gross salary
20,500€/year
Special requirement for DC1
Preselected applicants will have to complete a PhD entry exam in the subject area (mathematics) and a foreign language (English) exam, in accordance with Art. 9(1)-(2) of the Regulations for the Implementation of the Act on Academic Staff Development in the Republic of Bulgaria. The mathematics exam will consist of both written and oral components and will be based on a list of topics in mathematical modelling and numerical methods, which will be provided to the preselected applicants (Art. 3(1) from the Regulations on the Conditions and Order for Acquiring Scientific Degrees and Occupying Academic Positions at the Bulgarian Academy of Sciences).
This project may be adapted to the evolving needs of the host laboratory while remaining within hemato-oncology research. The DC will undertake one or more secondments with a total duration of at least three months and up to one year. These secondments may take place within or outside the DN, preferably in international and intersectoral settings.